Local likelihood disease clustering: development and evaluation

This paper illustrates a method based on local likelihood (LL) for detecting disease clusters. The approach is based on estimating a lasso distance for each region: within which regions are considered to be clustered. An important advantage in implementing this approach is that it does not require any special Monte Carlo Markov Chain (MCMC) algorithm, e.g., reversible jump MCMC, which is essential in hidden Markov model approach. Another advantage is that extending the model to incorporate covariates is straightforward. We illustrate three ways of doing this by using Eastern Germany lip cancer data. By using simulated data, we have made a comparison with the BYM model [Besag et al. (1991) Annals of the Institute of Statistical Mathematics, 43, 1–59] and the mixture model [Lawson and Clark (2002) Disease Mapping and Risk Assessment for Public Health, Chapman and Hall]. We also did a limited examination of the ability of the LL model to recover true relative risk under different priors for lasso parameter. In order to check the edge effects, which has been overlooked in many spatial clustering models for disease mapping but deserves special attention as it lacks observable neighbors, we have adapted here a simple approach to observe the changes in relative risks when the edge regions are omitted. An erratum to this article is available at .     

Relationship between the Aerodynamic Roughness Length and the Roughness Density in Cases of Low Roughness Density*

This paper presents measurements of roughness length performed in a wind tunnel for low roughness density. The experiments were performed with both compact and porous obstacles (clusters), in order to simulate the behavior of sparsely vegetated surfaces. The experimental results have been used to investigate the relationship between the ratio z₀/h and the roughness density, and the influence of an obstacle's porosity on this relationship. The experiments performed for four configurations of compact obstacles provide measurements of roughness length z₀ for roughness densities between 10^–3 and 10^–2 which are in good agreement with the only data set available until now for this range of low roughness densities. The results obtained with artificial porous obstacles suggests that the aerodynamic behavior of such roughness elements can be represented by the relationship established for compact obstacles, provided a porosity index has been used to determine the efficient roughness density (the fraction of the silhouette area actually sheltered by solid elements) rather than counting the porous object as solid. However, the experiments have been performed with relatively low porosity indices (maximum =25%) for which the porosity has a negligible influence. In this range of porosity index, representing the aerodynamic behavior of porous obstacles using the relationship established for compact obstacles, should not lead to a significant error. However, the influence of the porosity may be important for porosity indices larger than 30%.     

Auxin induced stress tolerance in algae

IAA effect on responses of West African algae Caloglosa, Bostrychia, Rhizoclonium and the fresh water alga Pithophora to different growth conditions was examined in growth chamber experiments. The auxin (2.28 x 10(-5) M) caused growth increase of 2.3- and 2.6-fold in Caloglossa and 1.6 and 1.7 in Rhizoclonium, respectively, in sea water and 1:1 diluted sea water/Erdschreiber medium. In Bostrychia pronounced deterioration of growth was noticed in the control samples between 16 and 32 days in culture. The cultures maintained an active growth, however, in the presence of IAA. IAA also allowed Pithophora to withstand salinity: Compared to growth in fresh water, a 65% growth inhibition was recorded in 1:1 diluted sea water in the absence of auxin and a slight growth stimulation when the auxin was present. Pithophora and Rhizoclonium also maintained higher rates of growth in extremal temperatures of 10 and 45 degrees C when the auxin was present.     

Evaluation of filter-based aerosol measurements during the 1987 Southern California Air Quality Study

The Southern California Air Quality Study (SCAQS) was conducted during the summer and fall of 1987 to assess the causes of elevated ozone and suspended particulate matter concentrations in California's South Coast Air Basin (SoCAB). Extensive gaseous (i.e. nitric acid, ammonia, sulfur dioxide) and particle (i.e. PM_2.5 and PM₁₀ mass, elements, ions, carbon) measurements were acquired for 11 days during the summer at nine locations, and six days during the fall at six locations. Outliers were identified so that they could be excluded from further statistical analyses. Carbon and elemental measurements were found to be negatively biased by 20% owing to inhomogenous aerosol deposits on the SCAQS filters and analysis methods which were applied to a portion of the filters. These biases seem relatively consistent, however, and should not affect conclusions drawn from data analysis efforts if they are appropriately considered. Significant fractions (30–60%) of ammonium nitrate volatilized during the summer when temperatures were higher. Less than 10% typically volatilized during the fall when temperatures were lower. Anion/cation balances support the accuracy and precision estimates of the nitrate, sulfate, and ammonium measurements. Coarse particle sulfate was generally low, while coarse particle nitrate was most pronounced at the coastal sites.This paper documents SCAQS filter-based aerosol measurement methods, and evaluates the accuracy, precision, and validity of the data set. Various comparisons were made for: (1) PM_2.5/PM₁₀ ratios for mass and major chemical species; (2) sum of chemical species versus measured mass; (3) sulfate versus sulfur ratios; (4) PM_2.5 particulate nitrate versus nitric acid-denuded nitrate; and (5) anion/cation balances. The measurement and evaluation techniques presented in this paper serve as a guideline for other data analysis and modeling studies.     

Atmospheric Emissions from Oxidation Ponds

The electrodes in industrial precipitators collect many tons of dust daily, and the efficient transfer of this dust burden to the hoppers is a challenging problem in mechanical engineering. Many varieties of devices have been tried; hammers, vibrators, scrapers, water flushing, gas blasting, etc. Impact devices for this purpose are usually called “rappers.” Laboratory experiments described in this paper show that normal (perpendicular) rapping is more effective than shear rapping; that thick dust layers are more easily removed by rapping than thin ones; that rapping becomes easier with increasing temperature, within limits; and that the electrostatic forces acting upon the precipitated dust layer play an important role. Quantitative data are shown graphically. The relation of these results to previous studies by other investigators is discussed.     

Household wood heater usage and indoor leakage of BTEX in Launceston,Australia: A null result

A study has been conducted in Launceston, Australia, to determine within households with wood heaters the effect of leakage from the heater and flue on the indoor air concentrations of the pollutants: benzene, toluene, ethylbenzene and xylene (BTEX). The study involved three classes: 28 households without wood heaters, 19 households with wood heaters compliant with the relevant Australian Standard and 30 households with non-compliant wood heaters. Outdoor and indoor BTEX concentrations were measured in each household for 7 days during summer when there was little or no wood heater usage, and for 7 days during winter when there was widespread wood heater usage. Each participant kept a household activity diary throughout their sampling periods. For wintertime, there were no significant differences of the indoor BTEX concentrations between the three classes of households. Also there were no significant relationships between BTEX indoor concentrations within houses and several measures of the amount of wood heater use within these houses. For the households sampled in this study, the use of a wood heater within a house did not lead to BTEX release within that house and had no direct detectable influence on the concentrations of BTEX within the house. We propose that the pressure differences associated with the both the leakiness or permeability of the building envelope and the draught of the wood heater have key roles in determining whether there will be backflow of smoke from the wood heater into the house. For a leaky house with a well maintained wood heater there should be no backflow of smoke from the wood heater into the house. However backflow of smoke may occur in well sealed houses.The study also found that wood heater emissions raise the outdoor concentrations of BTEX in winter in Launceston and through the mixing of outdoor air through the building envelopes into the houses, these emissions contribute to increases in the indoor concentrations of BTEX in winter in all houses in Launceston.